Studies 1 and 2 Combined

 

 

The effect of slow release insemination on pregnancy rates:

report of two randomized controlled pilot studies and meta-analysis

Julian Marschalek,1 Maximilian Franz,1 Yael Gonen,2 Jan-Steffen Kruessel,3 Amnon Weichselbaum,4 Lorenz Kuessel,1 Marie-Louise Trofaier,1 and Johannes Ott1

Heinrich Heine University, Düsseldorf, Germany, 2004 2007

Lin Medical Centre, Haifa, Israel, 2004 - 2007

IUI:  n = 44

SRI: n = 45

10 pregnancies were achieved:

3 with IUI  = PR of 6.8%

7 with SRI = PR of 15.6%

SRI relative risk of pregnancy = 2.28 compared with IUI

This did not reach statistical significance

There were no adverse events related to the use of SRI

 

The effect of slow release insemination on pregnancy rates:

report of two randomized controlled pilot studies and meta-analysis

The effect of slow release insemination on pregnancy rates:

report of two randomized controlled pilot studies and meta-analysis

Julian Marschalek,1 Maximilian Franz,1 Yael Gonen,2 Jan-Steffen Kruessel,3 Amnon Weichselbaum,4 Lorenz Kuessel,1 Marie-Louise Trofaier,1 and Johannes Ott1

Meta‑analysis of the combined study data for all eligible studies for SRI (n = 3)

Lin Medical Centre, Haifa, Israel  (2004 - 2007)

Heinrich Heine University, Düsseldorf. Germany (2004 - 2007)

Royal Free Hospital, London. UK  (1992)

 

Julian Marschalek,1 Maximilian Franz,1 Yael Gonen,2 Jan-Steffen Kruessel,3 Amnon Weichselbaum,4 Lorenz Kuessel,1 Marie-Louise Trofaier,1 and Johannes Ott1

Heinrich Heine University, Düsseldorf, Germany, 2004 2007

Lin Medical Centre, Haifa, Israel, 2004 2007

Effect of Age  - Under 35s Results

IUI:  n = 15

SRI: n = 20

8 pregnancies were achieved:

2 with IUI  = PR of 13%

8 with SRI = PR of 30%

SRI relative risk of pregnancy = 2.25 compared with IUI

This did not reach statistical significance

There were no adverse events related to the use of SRI

The meta-analysis shows that the combined relative risk of the three

studies is 2.64 p=0.02, indicating a statistically significant advantage

of SRI over conventional bolus IUI